ADCY7, adenylate cyclase 7, 113

N. diseases: 38; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.330 Biomarker disease BEFREE Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression? 30904753 2019
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease BEFREE Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression? 30904753 2019
CUI: C0344315
Disease: Depressed mood
Depressed mood 		0.020 Biomarker phenotype BEFREE Adenylyl cyclase 7 and neuropsychiatric disorders: A new target for depression? 30904753 2019
CUI: C0007766
Disease: Intracranial Aneurysm
Intracranial Aneurysm 		0.010 GeneticVariation disease BEFREE Four genes related to the estrogen receptor pathway were significantly associated with intracranial aneurysms, 2 of which were downregulated (PIK3R1: fold change [FC] = 0.41, false discovery rate [FDR] = 6.1 × 10<sup>-5</sup>, ADCY9: FC = 0.55, FDR = 2.3 × 10<sup>-4</sup>) and 2 of which were upregulated (HBEGF: FC = 1.46, FDR = 4.9 × 10<sup>-4</sup>; ADCY7: FC = 2.11, FDR = 6.0 × 10<sup>-3</sup>). 30831289 2019
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 GeneticVariation group GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0020676
Disease: Hypothyroidism
Hypothyroidism 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C3150797
Disease: AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6
AUTOIMMUNE DISEASE, SUSCEPTIBILITY TO, 6 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C4014795
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C4310768
Disease: AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2 		0.100 GeneticVariation disease GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Adenylate cyclase 7 (AC7) has been reported to participate in various biological processes during cancer progression. 30366671 2018
CUI: C0023487
Disease: Acute Promyelocytic Leukemia
Acute Promyelocytic Leukemia 		0.010 Biomarker disease BEFREE Taken together, our results show that miR-192-mediated AC7 could play important roles in differentiation of APL cells, AC7 and miR-192 might be new biomarkers and therapeutic targets for patients with relapsed APL. 30366671 2018
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.320 AlteredExpression disease BEFREE We further analyzed coexpression genes of CD300A and then screened two genes, ADCY7 and PECAM1, which were both overexpressed and associated with poor prognosis in AML. 29938007 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 Biomarker phenotype BEFREE Both PECAM1 and ADCY7 promoted tumor progression through the AKT pathway, showing the same molecular mechanism as CD300A. 29938007 2018
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 Biomarker disease CTD_human We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis. 28067910 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease GWASCAT We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis. 28067910 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease BEFREE We discovered a 0.6% frequency missense variant in ADCY7 that doubles the risk of ulcerative colitis. 28067910 2017
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.110 Biomarker group BEFREE Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7. 28067910 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases 		0.110 GeneticVariation group GWASCAT Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. 28067908 2017
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.410 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C3495559
Disease: Juvenile arthritis
Juvenile arthritis 		0.400 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.100 GeneticVariation group GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0007570
Disease: Celiac Disease
Celiac Disease 		0.100 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0009447
Disease: Common Variable Immunodeficiency
Common Variable Immunodeficiency 		0.100 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.100 GeneticVariation disease GWASCAT Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. 26301688 2015